Comparative Functional Genomic Analysis Identifies Distinct and Overlapping Sets of Genes Required for Resistance to Monomethylarsonous Acid (MMAIII) and Arsenite (AsIII) in Yeast
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چکیده
منابع مشابه
Comparative functional genomic analysis identifies distinct and overlapping sets of genes required for resistance to monomethylarsonous acid (MMAIII) and arsenite (AsIII) in yeast.
Arsenic is a human toxin and carcinogen commonly found as a contaminant in drinking water. Arsenite (As(III)) is the most toxic inorganic form, but recent evidence indicates that the metabolite monomethylarsonous acid (MMA(III)) is even more toxic. We have used a chemical genomics approach to identify the genes that modulate the cellular toxicity of MMA(III) and As(III) in the yeast Saccharomyc...
متن کاملComparative Functional Genomic Analysis Identifies Distinct and Overlapping Sets of Genes Required for Resistance to Monomethylarsonous Acid (MMA) and Arsenite (As) in Yeast
Arsenic is a human toxin and carcinogen commonly found as a contaminant in drinking water. Arsenite (As) is the most toxic inorganic form, but recent evidence indicates that the metabolite monomethylarsonous acid (MMA) is even more toxic. We have used a chemical genomics approach to identify the genes that modulate the cellular toxicity of MMA and As in the yeast Saccharomyces cerevisiae. Funct...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2009
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfp162